diff --git a/packages/playwright-core/src/client/elementHandle.ts b/packages/playwright-core/src/client/elementHandle.ts
index e3be4dc5e6..357192c2bf 100644
--- a/packages/playwright-core/src/client/elementHandle.ts
+++ b/packages/playwright-core/src/client/elementHandle.ts
@@ -284,7 +284,7 @@ export async function convertInputFiles(files: string | FilePayload | string[] |
       }));
       return { streams };
     }
-    return { localPaths: items as string[] };
+    return { localPaths: items.map(f => path.resolve(f as string)) as string[] };
   }
 
   const filePayloads: SetInputFilesFiles = await Promise.all(items.map(async item => {
diff --git a/packages/playwright-core/src/server/dispatchers/elementHandlerDispatcher.ts b/packages/playwright-core/src/server/dispatchers/elementHandlerDispatcher.ts
index 2b87644ba8..82eab5341d 100644
--- a/packages/playwright-core/src/server/dispatchers/elementHandlerDispatcher.ts
+++ b/packages/playwright-core/src/server/dispatchers/elementHandlerDispatcher.ts
@@ -24,7 +24,8 @@ import { JSHandleDispatcher, serializeResult, parseArgument } from './jsHandleDi
 import type { FrameDispatcher } from './frameDispatcher';
 import type { CallMetadata } from '../instrumentation';
 import type { WritableStreamDispatcher } from './writableStreamDispatcher';
-
+import { assert } from '../../utils';
+import path from 'path';
 export class ElementHandleDispatcher extends JSHandleDispatcher implements channels.ElementHandleChannel {
   _type_ElementHandle = true;
 
@@ -155,6 +156,8 @@ export class ElementHandleDispatcher extends JSHandleDispatcher implements chann
         throw new Error('Neither localPaths nor streams is specified');
       localPaths = params.streams.map(c => (c as WritableStreamDispatcher).path());
     }
+    for (const p of localPaths)
+      assert(path.isAbsolute(p) && path.resolve(p) === p, 'Paths provided to localPaths must be absolute and fully resolved.');
     return await this._elementHandle.setInputFiles(metadata, { localPaths }, params);
   }
 
diff --git a/packages/playwright-core/src/server/dispatchers/frameDispatcher.ts b/packages/playwright-core/src/server/dispatchers/frameDispatcher.ts
index 1fef3a3c73..771903dfca 100644
--- a/packages/playwright-core/src/server/dispatchers/frameDispatcher.ts
+++ b/packages/playwright-core/src/server/dispatchers/frameDispatcher.ts
@@ -25,6 +25,8 @@ import type { ResponseDispatcher } from './networkDispatchers';
 import { RequestDispatcher } from './networkDispatchers';
 import type { CallMetadata } from '../instrumentation';
 import type { WritableStreamDispatcher } from './writableStreamDispatcher';
+import { assert } from '../../utils';
+import path from 'path';
 
 export class FrameDispatcher extends Dispatcher<Frame, channels.FrameChannel> implements channels.FrameChannel {
   _type_Frame = true;
@@ -215,6 +217,8 @@ export class FrameDispatcher extends Dispatcher<Frame, channels.FrameChannel> im
         throw new Error('Neither localPaths nor streams is specified');
       localPaths = params.streams.map(c => (c as WritableStreamDispatcher).path());
     }
+    for (const p of localPaths)
+      assert(path.isAbsolute(p) && path.resolve(p) === p, 'Paths provided to localPaths must be absolute and fully resolved.');
     return await this._frame.setInputFiles(metadata, params.selector, { localPaths }, params);
   }
 
diff --git a/tests/page/page-set-input-files.spec.ts b/tests/page/page-set-input-files.spec.ts
index 2541db9f62..6530bd0a85 100644
--- a/tests/page/page-set-input-files.spec.ts
+++ b/tests/page/page-set-input-files.spec.ts
@@ -84,6 +84,55 @@ it('should upload large file', async ({ page, server, browserName, isMac }, test
   await Promise.all([uploadFile, file1.filepath].map(fs.promises.unlink));
 });
 
+it('should upload large file with relative path', async ({ page, server, browserName, isMac }, testInfo) => {
+  it.skip(browserName === 'webkit' && isMac && parseInt(os.release(), 10) < 20, 'WebKit for macOS 10.15 is frozen and does not have corresponding protocol features.');
+  it.slow();
+  await page.goto(server.PREFIX + '/input/fileupload.html');
+  const uploadFile = testInfo.outputPath('200MB.zip');
+  const str = 'A'.repeat(4 * 1024);
+  const stream = fs.createWriteStream(uploadFile);
+  for (let i = 0; i < 50 * 1024; i++) {
+    await new Promise<void>((fulfill, reject) => {
+      stream.write(str, err => {
+        if (err)
+          reject(err);
+        else
+          fulfill();
+      });
+    });
+  }
+  await new Promise(f => stream.end(f));
+  const input = page.locator('input[type="file"]');
+  const events = await input.evaluateHandle(e => {
+    const events = [];
+    e.addEventListener('input', () => events.push('input'));
+    e.addEventListener('change', () => events.push('change'));
+    return events;
+  });
+  const relativeUploadPath = path.relative(process.cwd(), uploadFile);
+  expect(path.isAbsolute(relativeUploadPath)).toBeFalsy();
+  await input.setInputFiles(relativeUploadPath);
+  expect(await input.evaluate(e => (e as HTMLInputElement).files[0].name)).toBe('200MB.zip');
+  expect(await events.evaluate(e => e)).toEqual(['input', 'change']);
+  const serverFilePromise = new Promise<formidable.File>(fulfill => {
+    server.setRoute('/upload', async (req, res) => {
+      const form = new formidable.IncomingForm({ uploadDir: testInfo.outputPath() });
+      form.parse(req, function(err, fields, f) {
+        res.end();
+        const files = f as Record<string, formidable.File>;
+        fulfill(files.file1);
+      });
+    });
+  });
+  const [file1] = await Promise.all([
+    serverFilePromise,
+    page.click('input[type=submit]')
+  ]);
+  expect(file1.originalFilename).toBe('200MB.zip');
+  expect(file1.size).toBe(200 * 1024 * 1024);
+  await Promise.all([uploadFile, file1.filepath].map(fs.promises.unlink));
+});
+
 it('should work @smoke', async ({ page, asset }) => {
   await page.setContent(`<input type=file>`);
   await page.setInputFiles('input', asset('file-to-upload.txt'));