diff --git a/tests/electron/electron-app.spec.ts b/tests/electron/electron-app.spec.ts
index 14771819f8..c221d51db4 100644
--- a/tests/electron/electron-app.spec.ts
+++ b/tests/electron/electron-app.spec.ts
@@ -48,7 +48,8 @@ test('should script application', async ({ electronApp }) => {
   expect(appPath).toBe(path.resolve(__dirname));
 });
 
-test('should preserve args', async ({ launchElectronApp }) => {
+test('should preserve args', async ({ launchElectronApp, isMac }) => {
+  test.fixme(isMac, 'https://github.com/microsoft/playwright/issues/21512');
   const electronApp = await launchElectronApp('electron-app-args.js', ['foo', 'bar']);
   const argv = await electronApp.evaluate(async () => globalThis.argv);
   expect(argv).toEqual([expect.stringContaining(path.join('dist', 'electron')), expect.stringContaining(path.join('electron', 'electron-app-args.js')), 'foo', 'bar']);
diff --git a/tests/library/capabilities.spec.ts b/tests/library/capabilities.spec.ts
index ad33e90da1..9b521062db 100644
--- a/tests/library/capabilities.spec.ts
+++ b/tests/library/capabilities.spec.ts
@@ -107,7 +107,8 @@ it('should play audio @smoke', async ({ page, server, browserName, platform }) =
   expect(await page.$eval('audio', e => e.currentTime)).toBeGreaterThan(0.2);
 });
 
-it('should support webgl @smoke', async ({ page, browserName, headless }) => {
+it('should support webgl @smoke', async ({ page, browserName, headless, browserMajorVersion, channel }) => {
+  it.fixme(channel === 'msedge' && browserMajorVersion === 111, 'https://github.com/microsoft/playwright/issues/21549');
   const hasWebGL = await page.evaluate(() => {
     const canvas = document.createElement('canvas');
     return !!canvas.getContext('webgl');
@@ -115,7 +116,8 @@ it('should support webgl @smoke', async ({ page, browserName, headless }) => {
   expect(hasWebGL).toBe(true);
 });
 
-it('should support webgl 2 @smoke', async ({ page, browserName, headless, isWindows }) => {
+it('should support webgl 2 @smoke', async ({ page, browserName, headless, isWindows, channel, browserMajorVersion }) => {
+  it.fixme(channel === 'msedge' && browserMajorVersion === 111, 'https://github.com/microsoft/playwright/issues/21549');
   it.skip(browserName === 'webkit', 'WebKit doesn\'t have webgl2 enabled yet upstream.');
   it.fixme(browserName === 'firefox' && isWindows);
   it.fixme(browserName === 'chromium' && !headless, 'chromium doesn\'t like webgl2 when running under xvfb');
diff --git a/tests/library/inspector/cli-codegen-2.spec.ts b/tests/library/inspector/cli-codegen-2.spec.ts
index 5183ab69ed..2fd0f89b43 100644
--- a/tests/library/inspector/cli-codegen-2.spec.ts
+++ b/tests/library/inspector/cli-codegen-2.spec.ts
@@ -104,7 +104,8 @@ test.describe('cli codegen', () => {
     expect(errors.length).toBe(0);
   });
 
-  test('should upload a single file', async ({ page, openRecorder, browserName, asset }) => {
+  test('should upload a single file', async ({ page, openRecorder, browserName, asset, isLinux }) => {
+    test.fixme(browserName === 'firefox' && isLinux, 'https://github.com/microsoft/playwright/issues/21550');
     const recorder = await openRecorder();
     await recorder.setContentAndWait(`
     <form>
@@ -134,7 +135,8 @@ test.describe('cli codegen', () => {
         await page.GetByRole(AriaRole.Textbox).SetInputFilesAsync(new[] { \"file-to-upload.txt\" });`);
   });
 
-  test('should upload multiple files', async ({ page, openRecorder, browserName, asset }) => {
+  test('should upload multiple files', async ({ page, openRecorder, browserName, asset, isLinux }) => {
+    test.fixme(browserName === 'firefox' && isLinux, 'https://github.com/microsoft/playwright/issues/21550');
     const recorder = await openRecorder();
     await recorder.setContentAndWait(`
     <form>
@@ -164,7 +166,8 @@ test.describe('cli codegen', () => {
         await page.GetByRole(AriaRole.Textbox).SetInputFilesAsync(new[] { \"file-to-upload.txt\", \"file-to-upload-2.txt\" });`);
   });
 
-  test('should clear files', async ({ page, openRecorder, browserName, asset }) => {
+  test('should clear files', async ({ page, openRecorder, browserName, asset, isLinux }) => {
+    test.fixme(browserName === 'firefox' && isLinux, 'https://github.com/microsoft/playwright/issues/21550');
     const recorder = await openRecorder();
     await recorder.setContentAndWait(`
     <form>
diff --git a/tests/library/trace-viewer.spec.ts b/tests/library/trace-viewer.spec.ts
index ff8b7123ee..d75764c5b6 100644
--- a/tests/library/trace-viewer.spec.ts
+++ b/tests/library/trace-viewer.spec.ts
@@ -25,6 +25,8 @@ const test = playwrightTest.extend<TraceViewerFixtures>(traceViewerFixtures);
 test.skip(({ trace }) => trace === 'on');
 test.slow();
 
+test.fixme(({ mode }) => mode === 'service' || mode === 'driver', 'https://github.com/microsoft/playwright/issues/21435');
+
 let traceFile: string;
 
 test.beforeAll(async function recordTrace({ browser, browserName, browserType, server }, workerInfo) {
diff --git a/tests/library/video.spec.ts b/tests/library/video.spec.ts
index 17cb788add..7cf3679285 100644
--- a/tests/library/video.spec.ts
+++ b/tests/library/video.spec.ts
@@ -512,7 +512,8 @@ it.describe('screencast', () => {
     expect(videoPlayer.videoHeight).toBe(600);
   });
 
-  it('should capture static page in persistent context @smoke', async ({ launchPersistent, browserName, trace }, testInfo) => {
+  it('should capture static page in persistent context @smoke', async ({ launchPersistent, browserName, trace, isMac }, testInfo) => {
+    it.skip(browserName === 'webkit' && isMac && process.arch === 'arm64', 'Is only failing on self-hosted github actions runner on M1 mac; not reproducible locally');
     const size = { width: 600, height: 400 };
     const { context, page } = await launchPersistent({
       recordVideo: {
diff --git a/tests/page/page-click.spec.ts b/tests/page/page-click.spec.ts
index 1c8a8dd6a3..2d4fe49e41 100644
--- a/tests/page/page-click.spec.ts
+++ b/tests/page/page-click.spec.ts
@@ -159,7 +159,9 @@ it('should select the text by triple clicking', async ({ page, server }) => {
   })).toBe(text);
 });
 
-it('should click offscreen buttons', async ({ page, server }) => {
+it('should click offscreen buttons', async ({ page, server, browserName, headless }) => {
+  it.fixme(!headless && browserName === 'firefox' && process.platform === 'darwin', 'https://github.com/microsoft/playwright/issues/20993');
+
   await page.goto(server.PREFIX + '/offscreenbuttons.html');
   const messages = [];
   page.on('console', msg => messages.push(msg.text()));
diff --git a/tests/page/page-screenshot.spec.ts b/tests/page/page-screenshot.spec.ts
index 9b2c472986..7d56f26ff1 100644
--- a/tests/page/page-screenshot.spec.ts
+++ b/tests/page/page-screenshot.spec.ts
@@ -277,7 +277,8 @@ it.describe('page screenshot', () => {
     expect(screenshot).toMatchSnapshot('screenshot-canvas.png');
   });
 
-  it('should capture canvas changes', async ({ page, isElectron, browserName, isMac, isWebView2 }) => {
+  it('should capture canvas changes', async ({ page, isElectron, browserName, isMac, channel, browserMajorVersion, isWebView2 }) => {
+    it.fixme(browserName === 'firefox' && channel === 'firefox-beta' && browserMajorVersion === 110, 'https://github.com/microsoft/playwright/issues/20522');
     it.fixme(browserName === 'webkit' && isMac, 'https://github.com/microsoft/playwright/issues/8796,https://github.com/microsoft/playwright/issues/16180');
     it.skip(isElectron);
     it.skip(isWebView2);